Article

Treatment of Murine Lupus with TIGIT-Ig

2019-03-25

Abstract excerpt

The TIGIT (T cell immunoreceptor with Ig and ITIM domains) protein is a co-inhibitory receptor that has been reported to suppress autoreactive T and B cells to trigger immunological tolerance. We generated a new recombinant protein by connecting the extracellular domain of murine TIGIT to the Fc region of the rat immunoglobulin IgG2a. The fusion protein was then characterized. The results suggested that among mice...

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Literature Corpus work: e72afab2-bd29-54cf-bc0b-111439f2b387
DOI: 10.1101/586321

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