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Article

Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.

The EMBO journal - 10 Jan 2007

Tinel Antoine, Janssens Sophie, Lippens Saskia, Cuenin Solange, Logette Emmanuelle, Jaccard Bastienne, Quadroni Manfredo, Tschopp Jürg

Abstract excerpt

Upon DNA damage, a complex called the PIDDosome is formed and either signals NF-kappaB activation and thus cell survival or alternatively triggers caspase-2 activation and apoptosis. PIDD (p53-induced protein with a death domain) is constitutively processed giving rise to a 48-kDa N-terminal fragment containing the leucine-rich repeats (LRRs, PIDD-N) and a 51-kDa C-terminal fragment containing the death domain...

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Identifiers

PMID: 17159900
DOI: 10.1038/sj.emboj.7601473
PMCID: PMC1782377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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