Article
CIDE domains form functionally important higher-order assemblies for DNA fragmentation.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jul 2017
Choi Jae Young, Qiao Qi, Hong Se-Hoon, Kim Chang Min, Jeong Jae-Hee, Kim Yeon-Gil, Jung Yong-Keun, Wu Hao, Park Hyun Ho
Abstract excerpt
Cell death-inducing DFF45-like effector (CIDE) domains, initially identified in apoptotic nucleases, form a family with diverse functions ranging from cell death to lipid homeostasis. Here we show that the CIDE domains of Drosophila and human apoptotic nucleases Drep2, Drep4, and DFF40 all form head-to-tail helical filaments. Opposing positively and negatively charged interfaces mediate the helical structures,...
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