Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.

Genes & development - 1 Dec 2006

Ouararhni Khalid, Hadj-Slimane Réda, Ait-Si-Ali Slimane, Robin Philippe, Mietton Flore, Harel-Bellan Annick, Dimitrov Stefan, Hamiche Ali

Abstract excerpt

The histone variant mH2A is believed to be involved in transcriptional repression, but how it exerts its function remains elusive. By using chromatin immunoprecipitation and tandem affinity immunopurification of the mH2A1.1 nucleosome complex, we identified numerous genes with promoters containing mH2A1.1 nucleosomes. In particular, the promoters of the inducible Hsp70.1 and Hsp70.2 genes, but not that of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to HSP70 Heat-Shock Proteins

Share to Nucleosomes

Share to Poly (ADP-Ribose) Polymerase-1

Share to Poly(ADP-ribose) Polymerases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 17158748
DOI: 10.1101/gad.396106
PMCID: PMC1686608

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The histone variant mH2A1.1 interferes with transcription by down-regulating PARP-1 enzymatic activity.PMID 17158748Read ↗

The histone variant macroH2A1.1 regulates RNA Polymerase II paused genes within defined chromatin interaction landscapesSemantic proximity Read ↗

Uncoupling of the transactivation and transrepression functions of PARP1 protein.Semantic proximity Read ↗

Joining the PARty: PARP Regulation of KDM5A during DNA Repair (and Transcription?)Semantic proximity Read ↗

AIRAP, a New Human Heat Shock Gene Regulated by Heat Shock Factor 1Semantic proximity Read ↗

FACT mediates the depletion of macroH2A1.2 to expedite gene transcription.Semantic proximity Read ↗

Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humansSemantic proximity Read ↗

Drosophila histone H2A variant (H2Av) controls poly(ADP-ribose) polymerase 1 (PARP1) activation in chromatin.Semantic proximity Read ↗

Gene expression regulation by heat-shock proteins: the cardinal roles of HSF1 and Hsp90.Semantic proximity Read ↗

Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.Semantic proximity Read ↗

The human Rap1 protein complex and modulation of telomere length.Semantic proximity Read ↗

The histone chaperone protein Nucleosome Assembly Protein-1 (hNAP-1) binds HIV-1 Tat and promotes viral transcriptionSemantic proximity Read ↗

Human PARP1 Facilitates Transcription through a Nucleosome and Histone Displacement by Pol II In VitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.