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Article

Uncoupling of the transactivation and transrepression functions of PARP1 protein.

Proceedings of the National Academy of Sciences of the United States of America - 6 Apr 2010

Kotova Elena, Jarnik Michael, Tulin Alexei V

Abstract excerpt

Poly(ADP ribose) polymerase 1 (PARP1) is a nuclear protein that regulates chromatin remodeling and transcription as well as DNA repair and genome stability pathways. Recent studies have revealed a paradoxical dual role of PARP1 protein in transcription. Specifically, although PARP1 controls transcriptional activation of a subset of genes that are heat shock- or hormone-dependent, it also directly inactivates...

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Source

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Identifiers

PMID: 20371698
DOI: 10.1073/pnas.0914152107
PMCID: PMC2851943

Genes

PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Uncoupling of the transactivation and transrepression functions of PARP1 protein.PMID 20371698Read ↗

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