Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

U7 snRNA: A tool for gene therapy

16 Feb 2021

Abstract excerpt

Most U-rich small nuclear ribonucleoproteins (snRNPs) are complexes that mediate the splicing of pre-mRNAs. U7 snRNP is an exception in that it is not involved in splicing but is a key factor in the unique 3' end processing of replication-dependent histone mRNAs. However, by introducing controlled changes in the U7 snRNA histone binding sequence and in the Sm motif, it can be used as an effective tool for gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33590603
DOI: 10.1002/jgm.3321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

U7 snRNA: A tool for gene therapyPMID 33590603Read ↗

Genetic therapies for RNA mis-splicing diseases.Semantic proximity Read ↗

Development of Engineered-U1 snRNA Therapies: Current Status.Semantic proximity Read ↗

RNA splicing: disease and therapy.Semantic proximity Read ↗

Therapeutic activity of modified U1 core spliceosomal particles.Semantic proximity Read ↗

How to Design U1 snRNA Molecules for Splicing Rescue.Semantic proximity Read ↗

A gene therapeutic approach to correct splice defects with modified U1 and U6 snRNPs.Semantic proximity Read ↗

Modulation of RNA Splicing by Oligonucleotides: Mechanisms of Action and Therapeutic ImplicationsSemantic proximity Read ↗

Spinal Muscular Atrophy: SMN2 Pre-mRNA Splicing Corrected by a U7 snRNA Derivative Carrying a Splicing Enhancer SequenceSemantic proximity Read ↗

Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development TherapeuticsSemantic proximity Read ↗

Antisense-mediated splice intervention to treat human disease: the odyssey continuesSemantic proximity Read ↗

Improvement of SMN2 Pre-mRNA Processing Mediated by Exon-Specific U1 Small Nuclear RNASemantic proximity Read ↗

Small nuclear RNAs enhance protein-free RNA-programmable base conversion on mammalian coding transcriptsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.