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Article

Mitochondrial DNA mutation detection by electrospray mass spectrometry.

Clinical chemistry - 1 Feb 2007

Jiang Yun, Hall Thomas A, Hofstadler Steven A, Naviaux Robert K

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) mutations cause a large spectrum of clinically important neurodegenerative, neuromuscular, cardiovascular, and endocrine disorders. We describe the novel application of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) to the rapid and accurate identification of pathogenic mtDNA variants. METHODS: In a blinded study, we used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

Share to Spectrometry, Mass, Electrospray Ionization

Source

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Identifiers

PMID: 17158195
DOI: 10.1373/clinchem.2006.074823
PMCID: PMC7108174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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