Article
Mass-spectrometry DNA sequencing.
Mutation research - 3 Jun 2005
Edwards John R, Ruparel Hameer, Ju Jingyue
Abstract excerpt
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been explored widely for DNA sequencing. Compared to gel electrophoresis based sequencing systems, mass spectrometry produces very high resolution of sequencing fragments, rapid separation on microsecond time scales, and completely eliminates compressions associated with gel-based systems. While most of the research...
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