Article
Genotyping single nucleotide polymorphisms using intact polymerase chain reaction products by electrospray quadrupole mass spectrometry.
Rapid communications in mass spectrometry : RCM - 1 Jan 2001
Walters J J, Muhammad W, Fox K F, Fox A, Xie D, Creek K E, Pirisi L
Abstract excerpt
Both single nucleotide polymorphisms (SNPs) and mutations are commonly observed in the gene encoding the tumor suppressor protein, p53. SNPs occur at specific locations within genes whereas mutations may be distributed across large regions of genes. When determining nucleotide differences, mass spectrometry is the only method other than Sanger sequencing which offers direct structural information. Electrospray...
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