Article
Complex NF-κB Interactions at the Distal Tumor Necrosis Factor Promoter Region in Human Monocytes
1 Aug 1998
Abstract excerpt
We describe a dense cluster of DNA-protein interactions located 600 nucleotides upstream of the transcriptional start site of the human tumor necrosis factor (TNF) gene. This area was identified as being of potential importance for lipopolysaccharide-inducible TNF expression in the human monocyte cell line Mono Mac 6, based on reporter gene analysis of point mutations at a number of nuclear factor kappaB...
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