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Article

EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells.

Journal of virology - 1 Mar 2007

Boccellato Francesco, Anastasiadou Eleni, Rosato Paola, Kempkes Bettina, Frati Luigi, Faggioni Alberto, Trivedi Pankaj

Abstract excerpt

Epstein-Barr virus (EBV)-negative diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma-derived cell lines infected in vitro with a recombinant EBV expressed type II/III latency. High expression of EBNA2 inversely correlated with expression of germinal center (GC)-associated genes, BCL6 and TCL1. The decreased expression of BCL6 appeared to be dose dependent, with almost complete abrogation in highly...

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Share to Burkitt Lymphoma
Share to Epstein-Barr Virus Nuclear Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germinal Center

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Lymphoma, Non-Hodgkin

Share to Proto-Oncogene Proteins c-bcl-6

Share to Viral Matrix Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 17151114
DOI: 10.1128/JVI.01822-06
PMCID: PMC1865942

Genes

BCL6
CCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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EBNA2 interferes with the germinal center phenotype by downregulating BCL6 and TCL1 in non-Hodgkin's lymphoma cells.PMID 17151114Read ↗

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