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Article

Epstein-Barr virus-associated Burkitt lymphomagenesis selects for downregulation of the nuclear antigen EBNA2.

Nature medicine - 1 Oct 2002

Kelly Gemma, Bell Andrew, Rickinson Alan

Abstract excerpt

Epstein-Barr virus (EBV) is etiologically linked to endemic Burkitt lymphoma (BL), but its contribution to lymphomagenesis, versus that of the chromosomal translocation leading to c-myc gene deregulation, remains unclear. The virus's growth-transforming (Latency III) program of gene expression is extinguished in tumor cells, and only a single viral protein, the EBV nuclear antigen (EBNA)1, is expressed via the...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epstein-Barr Virus Nuclear Antigens

Share to Gene Expression Regulation, Viral

Share to Herpesvirus 4, Human

Share to Proto-Oncogene Proteins c-myc

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Source

Identifiers

PMID: 12219084
DOI: 10.1038/nm758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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