Article
Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
Eukaryotic cell - 1 Mar 2012
Bastidas Robert J, Shertz Cecelia A, Lee Soo Chan, Heitman Joseph, Cardenas Maria E
Abstract excerpt
The zygomycete Mucor circinelloides is an opportunistic fungal pathogen that commonly infects patients with malignancies, diabetes mellitus, and solid organ transplants. Despite the widespread use of antifungal therapy in the management of zygomycosis, the incidence of infections continues to rise among immunocompromised individuals. In this study, we established that the target and mechanism of antifungal action...
Topics
- Animals
- Antifungal Agents
- Drug Resistance, Fungal
- Fungal Proteins
- Genetic Complementation Test
- Humans
- Immunosuppressive Agents
- Larva
- Moths
- Mucor
- Mutation
- Phylogeny
- Protein Binding
- Saccharomyces cerevisiae