Article
Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.
Developmental biology - 1 Mar 2007
Zechner Dietmar, Müller Thomas, Wende Hagen, Walther Ingrid, Taketo Makoto M, Crenshaw E Bryan, Treier Mathias, Birchmeier Walter, Birchmeier Carmen
Abstract excerpt
In the developing spinal cord, signals of the roof plate pattern the dorsal progenitor domain and control the specification of three neuron types, dorsal interneurons dI1, dI2, and dI3. Bmp and Wnt/beta-catenin signals as well as transcription factors like Olig3 or Ngn1/2 are essential in this process. We have studied the epistatic relationship between Bmp and Wnt/beta-catenin signals and the transcription factor...
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