Article
Comparative evaluation of nanofibrous scaffolding for bone regeneration in critical-size calvarial defects.
Tissue engineering. Part A - 1 Aug 2009
Woo Kyung Mi, Chen Victor J, Jung Hong-Moon, Kim Tae-Il, Shin Hong-In, Baek Jeong-Hwa, Ryoo Hyun-Mo, Ma Peter X
Abstract excerpt
In a previous study we found that nanofibrous poly(l-lactic acid) (PLLA) scaffolds mimicking collagen fibers in size were superior to solid-walled scaffolds in promoting osteoblast differentiation and bone formation in vitro. In this study we used an in vivo model to confirm the biological properties of nanofibrous PLLA scaffolds and to evaluate how effectively they support bone regeneration against solid-walled...
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