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Effects of Runx2 genetic engineering and <i>in vitro</i> maturation of tissue‐engineered constructs on the repair of critical size bone defects

14 Nov 2005

Abstract excerpt

Genetic and tissue engineering strategies are being pursued to address the clinical limitations of current bone grafting materials. Based on our previous work demonstrating that overexpression of the Runx2 osteoblastic transcription factor and in vitro construct maturation synergistically enhanced in vivo mineralization in an ectopic site (Byers et al., Tissue Eng 2004;10:1757-1766), we examined the effects of...

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PMID: 16287095
DOI: 10.1002/jbm.a.30549

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