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Article

Enhanced linkage of a locus on chromosome 2 to premature coronary artery disease in the absence of hypercholesterolemia.

European journal of human genetics : EJHG - 1 Mar 2007

Nsengimana Jérémie, Samani Nilesh J, Hall Alistair S, Balmforth Anthony J, Mangino Massimo, Yuldasheva Nadira, Maqbool Azhar, Braund Peter, Burton Paul, Bishop D Timothy, Ball Stephen G, Barrett Jennifer H

Abstract excerpt

Linkage studies of complex diseases have so far had limited success in producing significant and replicable results, in part owing to genetic heterogeneity. We recently reported the results of a large genome-wide linkage scan for coronary artery disease (CAD) based on 1933 families. The greatest evidence for linkage was to a region of chromosome 2, with a logarithm of odds (LOD) score of 1.86, based on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17149386
DOI: 10.1038/sj.ejhg.5201752

Genes

CAD
OSBPL6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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