Article
Serum lipids in the GENECARD study of coronary artery disease identify quantitative trait loci and phenotypic subsets on chromosomes 3q and 5q.
Annals of human genetics - 1 Nov 2006
Shah S H, Kraus W E, Crossman D C, Granger C B, Haines J L, Jones C J H, Mooser V, Huang L, Haynes C, Dowdy E, Vega G L, Grundy S M, Vance J M, Hauser E R
Abstract excerpt
Coronary artery disease (CAD) and dyslipidemia have strong genetic components. Heterogeneity complicates evaluating genetics of complex diseases such as CAD; incorporating disease-related phenotypes may help reduce heterogeneity. We hypothesized that incorporating lipoproteins in a study of CAD would increase the power to map genes, narrow linkage peaks, identify phenotypic subsets, and elucidate the contribution...
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