Article
Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus. The NHLBI Family Heart Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2000
Coon H, Myers R H, Borecki I B, Arnett D K, Hunt S C, Province M A, Djousse L, Leppert M F
Abstract excerpt
Familial combined hyperlipidemia (FCHL), the most common familial dyslipidemia, is implicated in up to 20% of cases of premature coronary heart disease. Although underlying mutations for FCHL have yet to be identified, several candidate genes/regions have been identified. A positive linkage to chromosome 1q markers has been reported, with the highest lod score of 5.93 occurring at a location between D1S104 and...
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