Article
PGJ2-stimulated beta-cell apoptosis is associated with prolonged UPR activation.
American journal of physiology. Endocrinology and metabolism - 1 Apr 2007
Chambers Kari T, Weber Sarah M, Corbett John A
Abstract excerpt
Peroxisome proliferator-activated receptor-gamma (PPARgamma) ligands have been shown to possess anti-inflammatory properties that include the inhibition of transcription factor activation and the expression of inflammatory genes. Using pancreatic beta-cells, we have shown that PPARgamma ligands such as 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ(2)) attenuate interferon-gamma-induced signal transducer and...
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