Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling.

Molecular and cellular biology - 1 Jul 2003

Sanchez Joseph F, Sniderhan Lynn F, Williamson Andrea L, Fan Shongshan, Chakraborty-Sett Shikha, Maggirwar Sanjay B

Abstract excerpt

Recent studies have revealed a positive correlation between astrocyte apoptosis and rapid disease progression in persons with neurodegenerative diseases. Glycogen synthase kinase 3beta (GSK-3beta) is a molecular regulator of cell fate in the central nervous system and a target of the phosphatidylinositol 3-kinase (PI-3K) pathway. We have therefore examined the role of the PI-3K pathway, and of GSK-3beta, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to I-kappa B Kinase

Share to In Situ Nick-End Labeling

Share to Prostaglandin-Endoperoxide Synthases

Source

Open in PubMed Open full text

Identifiers

PMID: 12808104
DOI: 10.1128/MCB.23.13.4649-4662.2003
PMCID: PMC164840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glycogen synthase kinase 3beta-mediated apoptosis of primary cortical astrocytes involves inhibition of nuclear factor kappaB signaling.PMID 12808104Read ↗

Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival.Semantic proximity Read ↗

Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice.Semantic proximity Read ↗

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor κB target genes and induction of apoptosis in chronic lymphocytic leukemia B cellsSemantic proximity Read ↗

Recent advances in understanding the cellular roles of GSK-3Semantic proximity Read ↗

Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.Semantic proximity Read ↗

GSK-3 is a master regulator of neural progenitor homeostasis.Semantic proximity Read ↗

Function of GSK‑3 signaling in spinal cord injury (Review)Semantic proximity Read ↗

Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.Semantic proximity Read ↗

GSK‐3 in Neurodegenerative DiseasesSemantic proximity Read ↗

Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cellsSemantic proximity Read ↗

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read ↗

Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.