Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis.

Autoimmunity - 1 Jun 2006

Deitiker Philip R, Oshima Minako, Smith R Glenn, Mosier Dennis R, Atassi M Zouhair

Abstract excerpt

The HLA DQA1 and DQB1 alleles were determined on a set of 24 myasthenia gravis patients that had previously been examined for their T-cell proliferative responses to the 18 overlapping peptides representing the extracellular domain of hAChR alpha-chain. Patient responses according to assumed cis or trans haplotypes were significantly higher in most cases relative to normal controls. Comparisons of in vitro...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HLA-DQ alpha-Chains
Share to HLA-DQ Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-DQ beta-Chains

Share to Lymphocyte Activation

Share to Membrane Glycoproteins

Share to Myasthenia Gravis

Share to Protein Subunits

Share to Receptors, Cholinergic

Source

Identifiers

PMID: 16891216
DOI: 10.1080/08916930600738581

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis.PMID 16891216Read ↗

Critical role for the Val/Gly86 HLA-DR beta dimorphism in autoantigen presentation to human T cells.Semantic proximity Read ↗

Trans-encoded DQ alpha beta heterodimers confer susceptibility to myasthenia gravis disease.Semantic proximity Read ↗

HLA genotypes in Turkish patients with myasthenia gravis: comparison with multiple sclerosis patients on the basis of clinical subtypes and demographic features.Semantic proximity Read ↗

Different HLA DR-DQ associations in subgroups of idiopathic myasthenia gravisSemantic proximity Read ↗

Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasiaSemantic proximity Read ↗

Myasthenia gravis patients with thymus hyperplasia and myasthenia gravis patients with thymoma display different HLA associations.Semantic proximity Read ↗

Targeting the antigen-binding site of HLA-restricting alleles in treatment of autoimmune disease.Semantic proximity Read ↗

Scanning a DRB3*0101 (DR52a)-restricted epitope cross-presented by DR3: overlapping natural and artificial determinants in the human acetylcholine receptor.Semantic proximity Read ↗

Determinant spreading and immune responses to acetylcholine receptors in myasthenia gravisSemantic proximity Read ↗

Cross-restriction of a T cell clone to HLA-DR alleles associated with rheumatoid arthritis: clues to arthritogenic peptide motifs.Semantic proximity Read ↗

Differential effect of polymorphism at HLA-DR1 beta-chain positions 85 and 86 on binding and recognition of DR1-restricted antigenic peptides.Semantic proximity Read ↗

T-cell recognition of acetylcholine receptor provides a reliable means for monitoring autoimmunity to acetylcholine receptor in antibody-negative myasthenia gravis patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.