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Article

Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2006

Hastings K Taraszka, Lackman Rebecca L, Cresswell Peter

Abstract excerpt

Ag processing and presentation via MHC class II is essential for activation of CD4(+) T lymphocytes. gamma-IFN-inducible lysosomal thiol reductase (GILT) is present in the MHC class II loading compartment and has been shown to facilitate class II Ag processing and recall responses to Ags containing disulfide bonds such as hen egg lysozyme (HEL). Reduction of proteins within the MHC class II loading compartment is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17142755
DOI: 10.4049/jimmunol.177.12.8569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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