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Article

N-glycosylation enhances presentation of a MHC class I-restricted epitope from tyrosinase.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2009

Ostankovitch Marina, Altrich-Vanlith Michelle, Robila Valentina, Engelhard Victor H

Abstract excerpt

We recently demonstrated that the mechanism of processing of an HLA-A*0201-restricted peptide epitope, Tyr(369)(D), derived from the membrane protein tyrosinase, involves retrotranslocation of glycosylated molecules from the endoplasmic reticulum to the cytosol, removal of an N-linked carbohydrate from Asn(371) by peptide N-glycanase, proteolysis by the proteasome and other proteases, and retransport of the...

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Identifiers

PMID: 19342661
DOI: 10.4049/jimmunol.0802902
PMCID: PMC2859980

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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