Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity.

European journal of immunology - 1 Jan 2013

Phipps-Yonas Hannah, Semik Vikki, Hastings Karen Taraszka

Abstract excerpt

MHC class II-restricted Ag processing requires protein degradation in the endocytic pathway for the activation of CD4(+) T cells. Gamma-interferon-inducible lysosomal thiol reductase (GILT) facilitates Ag processing by reducing protein disulfide bonds in this compartment. Lysosomal cysteine prote...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Cathepsins
Share to Lysosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Oxidoreductases

Share to Oxidoreductases Acting on Sulfur Group Donors

Share to Protein Processing, Post-Translational

Share to Protein Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 23012103
DOI: 10.1002/eji.201242379
PMCID: PMC3706190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23012103-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity.PMID 23012103Read ↗

Functional requirements for the lysosomal thiol reductase GILT in MHC class II-restricted antigen processing.Semantic proximity Read ↗

IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells.Semantic proximity Read ↗

Role of Disulfide Bonds in Regulating Antigen Processing and Epitope SelectionSemantic proximity Read ↗

Interferon-induced lysosomal membrane permeabilization and death cause cDC1-deserts in tumorsSemantic proximity Read ↗

Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteinsSemantic proximity Read ↗

Role of canonical and noncanonical autophagy pathways in shaping the life journey of B cellsSemantic proximity Read ↗

A cathepsin C-like protease post-translationally modifies <i>Toxoplasma gondii</i> secretory proteins for optimal invasion and egressSemantic proximity Read ↗

TFEB regulates lysosomal proteostasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.