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Article

The oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I molecules.

The EMBO journal - 3 Jun 2002

Antoniou Antony N, Ford Stuart, Alphey Magnus, Osborne Andrew, Elliott Tim, Powis Simon J

Abstract excerpt

The oxidoreductase ERp57 is an integral component of the peptide loading complex of major histocompatibility complex (MHC) class I molecules, formed during their chaperone-assisted assembly in the endoplasmic reticulum. Misfolded MHC class I molecules or those denied suitable peptides are retrotranslocated and degraded in the cytosol. The presence of ERp57 during class I assembly suggests it may be involved in...

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Identifiers

PMID: 12032078
DOI: 10.1093/emboj/21.11.2655
PMCID: PMC126025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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