Article
Altered enhancer transcription underlies Huntington's disease striatal transcriptional signature.
Scientific reports - 22 Feb 2017
Le Gras Stéphanie, Keime Céline, Anthony Anne, Lotz Caroline, De Longprez Lucie, Brouillet Emmanuel, Cassel Jean-Christophe, Boutillier Anne-Laurence, Merienne Karine
Abstract excerpt
Epigenetic and transcriptional alterations are both implicated in Huntington's disease (HD), a progressive neurodegenerative disease resulting in degeneration of striatal neurons in the brain. However, how impaired epigenetic regulation leads to transcriptional dysregulation in HD is unclear. Here, we investigated enhancer RNAs (eRNAs), a class of long non-coding RNAs transcribed from active enhancers. We found...
Topics
- Animals
- Corpus Striatum
- Disease Models, Animal
- Enhancer Elements, Genetic
- Gene Expression Profiling
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Humans
- Huntington Disease
- Mice
- RNA Polymerase II