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Article

Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6.

DNA repair - 1 Mar 2007

Holmes Shannon F, Scarpinato Karin Drotschmann, McCulloch Scott D, Schaaper Roel M, Kunkel Thomas A

Abstract excerpt

The major eukaryotic mismatch repair (MMR) pathway requires Msh2-Msh6, which, like Escherichia coli MutS, binds to and participates in repair of the two most common replication errors, single base-base and single base insertion-deletion mismatches. For both types of mismatches, the side chain of E. coli Glu38 in a conserved Phe-X-Glu motif interacts with a mismatched base. The Ovarepsilon of Glu38 forms a...

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Identifiers

PMID: 17141577
DOI: 10.1016/j.dnarep.2006.10.023
PMCID: PMC1839834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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