Article
Function of the asparagine 74 residue of the inhibitory γ-subunit of retinal rod cGMP-phophodiesterase (PDE) in vivo.
Cellular signalling - 1 Oct 2011
Tsang Stephen H, Woodruff Michael L, Hsu Chun Wei, Naumann Matthew C, Cilluffo Marianne, Tosi Joaquin, Lin Chyuan-Sheng
Abstract excerpt
The inhibitory subunit of rod cyclic guanosine monophosphate (cGMP) phosphodiesterase, PDE6γ, is a major component of rod transduction and is required to support photoreceptor integrity. The N74A allele of PDE6γ has previously been shown in experiments carried out in vitro to reduce the regulatory inhibition on the PDE6 catalytic core subunits, PDE6αβ. This should, in intact rods, lead to an increase in basal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.