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Article

Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C.

Gut - 1 May 2007

Sartori Massimo, Andorno Silvano, Pagliarulo Michela, Rigamonti Cristina, Bozzola Cristina, Pergolini Patrizia, Rolla Roberta, Suno Anna, Boldorini Renzo, Bellomo Giorgio, Albano Emanuele

Abstract excerpt

BACKGROUND: Iron accumulation is a well-known risk factor for the progression of chronic hepatitis C (CHC) to fibrosis. However, the profibrogenic role of the genes controlling iron homeostasis is still controversial. AIM: To evaluate the relative role of haemachromatosis (HFE), ferroportin and beta-globin gene mutations in promoting iron accumulation and fibrosis in patients with CHC. METHODS: Genetic analysis...

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Source

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Identifiers

PMID: 17135308
DOI: 10.1136/gut.2006.106641
PMCID: PMC1942129

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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