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Article

Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C.

Hepatology (Baltimore, Md.) - 1 Jun 1998

Smith B C, Gorve J, Guzail M A, Day C P, Daly A K, Burt A D, Bassendine M F

Abstract excerpt

Hepatic iron has been associated with more aggressive liver disease in chronic viral hepatitis. We evaluated whether the recently described C282Y mutation of the hemochromatosis gene, designated HFE (responsible for at least 83% of hereditary hemochromatosis), was associated with more advanced li...

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Source

Identifiers

PMID: 9620344
DOI: 10.1002/hep.510270631

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9620344-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Heterozygosity for hereditary hemochromatosis is associated with more fibrosis in chronic hepatitis C.PMID 9620344Read ↗

Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C.Semantic proximity Read ↗

Heterozygosity for the hemochromatosis gene in liver diseases--prevalence and effects on liver histology.Semantic proximity Read ↗

Heterozygous beta-globin gene mutations as a risk factor for iron accumulation and liver fibrosis in chronic hepatitis C.Semantic proximity Read ↗

Hemochromatosis gene mutations in chronic hepatitis C patients with and without liver siderosis.Semantic proximity Read ↗

Differences in hepatic phenotype between hemochromatosis patients with HFE C282Y homozygosity and other HFE genotypes.Semantic proximity Read ↗

HFE C282Y heterozygosity in hepatocellular carcinoma: evidence for an increased prevalence.Semantic proximity Read ↗

Heterozygotes for HFE mutations have no increased risk of advanced alcoholic liver disease.Semantic proximity Read ↗

HFE mutations and chronic hepatitis C: H63D and C282Y heterozygosity are independent risk factors for liver fibrosis and cirrhosis.Semantic proximity Read ↗

Iron and HFE or TfR1 mutations as comorbid factors for development and progression of chronic hepatitis C.Semantic proximity Read ↗

Liver pathology in compound heterozygous patients for hemochromatosis mutations.Semantic proximity Read ↗

Hemochromatosis and transferrin receptor gene polymorphisms in chronic hepatitis C: impact on iron status, liver injury and HCV genotype.Semantic proximity Read ↗

Hfe mutations and iron overload in patients with alcoholic liver disease.Semantic proximity Read ↗

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