Article
Common heterozygous hemochromatosis gene mutations are risk factors for inflammation and fibrosis in chronic hepatitis C.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2004
Geier Andreas, Reugels Michael, Weiskirchen Ralf, Wasmuth Hermann E, Dietrich Christoph G, Siewert Elmar, Gartung Carsten, Lorenzen Johann, Bosserhoff Anja K, Brügmann Marc, Gressner Axel M, Matern Siegfried, Lammert Frank
Abstract excerpt
BACKGROUND: Chronic hepatitis C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of hemochromatosis genes affect fibrosis progression. Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in German hepatitis C patients. METHODS: Liver biopsies from 166 patients were scored for...
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