Article
Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.
Cell death and differentiation - 1 Dec 2018
Fang Ling, Du William W, Lyu Juanjuan, Dong Jun, Zhang Chao, Yang Weining, He Alina, Kwok Yat Sze Sheila, Ma Jian, Wu Nan, Li Feiya, Awan Faryal Mehwish, He Chengyan, Yang Bing L, Peng Chun, MacKay Helen J, Yee Albert J, Yang Burton B
Abstract excerpt
TP53 mutations occur in many different types of cancers that produce mutant p53 proteins. The mutant p53 proteins have lost wild-type p53 activity and gained new functions that contribute to malignant tumor progression. Different p53 mutations create distinct profiles in loss of wild-type p53 activity and gain of functions. Targeting the consequences generated by the great number of p53 mutations would be...
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