The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.

doi:10.1093/rheumatology/kel381

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Article

The 620W allele is the PTPN22 genetic variant conferring susceptibility to RA in a Dutch population.

Rheumatology (Oxford, England) - 1 Apr 2007

Wesoly J, Hu X, Thabet M M, Chang M, Uh H, Allaart C F, Toes R E M, Houwing-Duistermaat J J, Begovich A B, Huizinga T W J

Abstract excerpt

OBJECTIVES: A missense SNP, C1858T, in PTPN22 has been identified as a genetic risk factor for rheumatoid arthritis (RA). Subsequent work has suggested that other variants in this gene, in particular a haplotype marked by the minor allele of rs3789604, are associated with RA in white North Americans independent of C1858T. We tested this hypothesis in an independent white Dutch study. METHODS: A total of 667 RA...

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PMID: 17135225
DOI: 10.1093/rheumatology/kel381

Genes

PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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