Potentiation of early hematopoiesis by tumor necrosis factor-alpha is followed by inhibition of granulopoietic differentiation and proliferation.

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Article

Potentiation of early hematopoiesis by tumor necrosis factor-alpha is followed by inhibition of granulopoietic differentiation and proliferation.

Blood - 1 Aug 1991

Caux C, Favre C, Saeland S, Duvert V, Durand I, Mannoni P, Banchereau J

Abstract excerpt

We have previously shown that tumor necrosis factor-alpha (TNF alpha) strongly potentiates interleukin-3 (IL-3)-induced short-term proliferation of human CD34+ hematopoietic progenitor cells (HPC). Using longer term cultures of CD34+ HPC, we demonstrate here that this initial potentiation ceases after 10 to 12 days; whereupon TNF alpha displays inhibitory effects. Thus, TNF alpha was found to inhibit cells of...

Topics

Antibodies, Monoclonal
Antigens, CD
Antigens, CD34
Cell Differentiation
Cell Division
Cells, Cultured
Colony-Forming Units Assay
Female
Fetal Blood
Granulocytes
Hematopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant, Newborn

Interleukin-3

Kinetics

Phenotype

Pregnancy

Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 1713509

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1713509-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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