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Article

Megakaryocytic differentiation of human progenitor cells is negatively influenced by direct contact with stroma.

Leukemia - 1 Jun 1999

Zweegman S, Veenhof M A, Debili N, Schuurhuis G J, Huijgens P C, Dräger A M

Abstract excerpt

The recently defined ligand for the Mpl receptor, thrombopoietin (TPO), has been found to be the principal regulatory cytokine of megakaryocytopoiesis. Furthermore, it has been hypothesized that direct interaction between stroma or stroma-derived extracellular matrix (ECM) and human progenitor cells (HPC) may modulate megakaryocytopoiesis. For that purpose, we studied megakaryocytic development of HPC, obtained...

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Source

Identifiers

PMID: 10360383
DOI: 10.1038/sj.leu.2401422

Genes

TPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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