Megakaryocyte progenitors derived from bone marrow or G-CSF-mobilized peripheral blood CD34 cells show a distinct phenotype and responsiveness to interleukin-3 (IL-3) and PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF).

doi:10.1046/j.1365-2141.1998.00511.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Megakaryocyte progenitors derived from bone marrow or G-CSF-mobilized peripheral blood CD34 cells show a distinct phenotype and responsiveness to interleukin-3 (IL-3) and PEG-recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF).

British journal of haematology - 1 Jan 1998

Catani L, Gugliotta L, Campanini E, Mangianti S, Gibellini D, Baravelli S, Vianelli N, Lemoli R M, Tura S

Abstract excerpt

In the present study we investigated the proliferative response of megakaryocyte progenitor cells (CFU-MK) derived from peripheral blood stem cell (PBSC) collections of patients with haematological malignancies and normal donors. Highly purified CD34+ cells and mononuclear cell fractions were assayed in the presence of recombinant interleukin-3 (IL-3) and pegylated-recombinant human megakaryocyte growth and...

Topics

Antigens, CD34
Colony-Forming Units Assay
Dose-Response Relationship, Drug
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Humans
Interleukin-3
Megakaryocytes
Neoplasm Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Polyethylene Glycols

Proto-Oncogene Proteins

Receptors, Cytokine

Receptors, Thrombopoietin

Recombinant Proteins

Thrombopoietin

Source

Open in PubMed

Identifiers

PMID: 9450813
DOI: 10.1046/j.1365-2141.1998.00511.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.