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Article

No association of TLR2 and TLR4 polymorphisms with type I diabetes mellitus in the Basque population.

Annals of the New York Academy of Sciences - 1 Oct 2006

Santin Izortze, Bilbao Jose Ramon, de Nanclares Guiomar Pérez, Calvo Begoña, Castaño Luis

Abstract excerpt

The destruction of pancreatic beta cells that occurs in type 1 diabetes mellitus (T1DM) is mediated by the immune system, and evidence has accumulated supporting the implication of innate immune mediators. Toll-like receptors (TLRs) participate in the first line of immune defense through antigen recognition, and their ligands are mostly exogenous but can be host-derived as well. To test the possible role of TLRs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17130564
DOI: 10.1196/annals.1375.040

Genes

TLR4
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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