Article
Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients.
Journal of neuroimmunology - 1 Jan 2007
Weinstock-Guttman Bianca, Tamaño-Blanco Miriam, Bhasi Kavitha, Zivadinov Robert, Ramanathan Murali
Abstract excerpt
The myxovirus resistance A (MXA) mRNA has been extensively investigated for assessing the biologic responses of multiple sclerosis (MS) patients to interferon-beta (IFN-beta) therapy. The objective of this study was to evaluate the associations between two MXA promoter region single nucleotide polymorphisms (rs2071430 and rs17000900) and the gene expression responses, clinical and MRI phenotypes in IFN-beta...
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