Article
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis.
Archives of neurology - 1 Mar 2008
Byun Esther, Caillier Stacy J, Montalban Xavier, Villoslada Pablo, Fernández Oscar, Brassat David, Comabella Manuel, Wang Joanne, Barcellos Lisa F, Baranzini Sergio E, Oksenberg Jorge R
Abstract excerpt
OBJECTIVE: To identify promising candidate genes linked to interindividual differences in the efficacy of interferon beta therapy. Recombinant interferon beta therapy is widely used to reduce disease activity in multiple sclerosis (MS). However, up to 50% of patients continue to have relapses and worsening disability despite therapy. DESIGN: We used a genome-wide pharmacogenomic approach to identify...
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