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Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.

Developmental biology - 1 Mar 2007

Ribes Vanessa, Otto Diana M E, Dickmann Leslie, Schmidt Katy, Schuhbaur Brigitte, Henderson Colin, Blomhoff Rune, Wolf C Roland, Tickle Cheryll, Dollé Pascal

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) acts as an electron donor for all cytochrome P450 enzymes. Knockout mouse Por(-/-) mutants, which are early embryonic (E9.5) lethal, have been found to have overall elevated retinoic acid (RA) levels, leading to the idea that POR early developmental function is mainly linked to the activity of the CYP26 RA-metabolizing enzymes (Otto et al., Mol. Cell. Biol. 23, 6103-6116). By...

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PMID: 17126317
DOI: 10.1016/j.ydbio.2006.10.032

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POR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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