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Article

Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis.

Molecular and cellular biology - 1 Sept 2003

Otto Diana M E, Henderson Colin J, Carrie Dianne, Davey Megan, Gundersen Thomas E, Blomhoff Rune, Adams Ralf H, Tickle Cheryll, Wolf C Roland

Abstract excerpt

The cytochrome P450-dependent monooxygenase system catalyzes the metabolism of xenobiotics and endogenous compounds, including hormones and retinoic acid. In order to establish the role of these enzymes in embryogenesis, we have inactivated the system through the deletion of the gene for the elec...

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Identifiers

PMID: 12917333
DOI: 10.1128/MCB.23.17.6103-6116.2003
PMCID: PMC180925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12917333-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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