Article
Molecular parameters associated with insulinoma progression: chromosomal instability versus p53 and CK19 status.
Cytogenetic and genome research - 1 Jan 2006
Jonkers Y M H, Claessen S M H, Veltman J A, Geurts van Kessel A, Dinjens W N M, Skogseid B, Ramaekers F C S, Speel E-J M
Abstract excerpt
Insulinomas represent the predominant syndromic subtype of endocrine pancreatic tumors (EPTs). Their metastatic potential cannot be predicted reliably using histopathological criteria. In the past few years, several attempts have been made to identify prognostic markers, among them TP53 mutations and immunostaining of p53 and recently cytokeratin 19 (CK19). In a previous study using conventional comparative...
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