Article
Multiple genetic alterations in malignant metastatic insulinomas.
The Journal of pathology - 1 Dec 1995
Pavelić K, Hrasćan R, Kapitanović S, Karapandza N, Vranes Z, Belicza M, Kruslin B, Cabrijan T
Abstract excerpt
Proto-oncogenes, growth factors/receptors, and tumour suppressor genes were analysed in malignant metastatic insulinomas. Normal pancreas showed only a moderate immunoreaction for c-myc proto-oncogene and a strong reaction for insulin. Benign insulinomas were slightly or moderately positive for transforming growth factor alpha (TGF alpha), weakly positive for epidermal growth factor receptor (EGF-R), and strongly...
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