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Genomic instability and copy‐number heterogeneity of chromosome 19q, including the kallikrein locus, in ovarian carcinomas

11 Aug 2010

Abstract excerpt

Many tissue kallikrein (KLK) genes and proteins are candidate diagnostic, prognostic and predictive biomarkers for ovarian cancer (OCa). We previously demonstrated that the KLK locus (19q13.3/4) is subject to copy-number gains and structural rearrangements in a pilot study of cell lines and ovarian cancer primary tissues, shown to overexpress KLK gene family members. To determine the overall frequency of genomic...

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PMID: 20800559
DOI: 10.1016/j.molonc.2010.08.002

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