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Article

Chromosomal instability in the prediction of pituitary neuroendocrine tumors prognosis.

Acta neuropathologica communications - 10 Nov 2020

Lasolle Hélène, Elsensohn Mad-Hélénie, Wierinckx Anne, Alix Eudeline, Bonnefille Clément, Vasiljevic Alexandre, Cortet Christine, Decoudier Bénédicte, Sturm Nathalie, Gaillard Stephan, Ferrière Amandine, Roy Pascal, Jouanneau Emmanuel, Bertolino Philippe, Bardel Claire, Sanlaville Damien, Raverot Gérald

Abstract excerpt

The purpose of this study was to analyze the impact of copy number variations (CNV) on sporadic pituitary neuroendocrine tumors (PitNETs) prognosis, to identify specific prognosis markers according to the known clinico-pathological classification. CGH array analysis was performed on 195 fresh-frozen PitNETs (56 gonadotroph, 11 immunonegative, 56 somatotroph, 39 lactotroph and 33 corticotroph), with 5 years...

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Identifiers

PMID: 33168091
DOI: 10.1186/s40478-020-01067-5
PMCID: PMC7653703

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