Article
TNFA-308G>A polymorphism influences the TNF-alpha response to altered vaginal flora.
European journal of obstetrics, gynecology, and reproductive biology - 1 Oct 2007
Genç Mehmet R, Vardhana Santosh, Delaney Mary L, Witkin Steven S, Onderdonk Andrew B
Abstract excerpt
OBJECTIVE: To investigate the association between a tumor necrosis factor-alpha (TNF-alpha) gene polymorphism, vaginal TNF-alpha level, and microbial flora in pregnant women. METHODS: Vaginal samples from 203 women at 18-22 weeks' gestation were analyzed for microflora. TNFA-308G>A polymorphism was analyzed by polymerase chain reaction and restriction endonuclease analysis and TNF-alpha concentration was...
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