Article
Interplay of cytokine polymorphisms and bacterial vaginosis in the etiology of preterm delivery.
Journal of reproductive immunology - 1 Dec 2010
Jones Nicole M, Holzman Claudia, Friderici Karen H, Jernigan Katherine, Chung Hwan, Wirth Julia, Fisher Rachel
Abstract excerpt
Recent findings suggest that the association between inflammation-related genes and preterm delivery may be stronger in the presence of bacterial vaginosis (BV). Tumor necrosis factor-alpha (TNFα) and interleukin 1-beta (IL-1β) are pro-inflammatory cytokines capable of inducing preterm labor in non-human primates. In this study the authors tested associations among two TNFα promoter polymorphisms (-G308A and...
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