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Article

The major population of PHA-stimulated PBMC infected by R5 or X4 HIV variants after a single cycle of infection is predominantly composed of CD45RO+CD4+ T lymphocytes.

Archives of virology - 1 Jan 2007

Holl V, Schmidt S, Aubertin A-M, Moog C

Abstract excerpt

PHA-stimulated peripheral blood mononuclear cells (PBMCs) are widely used for investigating replication and neutralization of HIV primary isolates in vitro. The objective of this study was to identify the T lymphocyte subset(s) that are found infected after one replication cycle by either R5- or X4-HIV-1 variants in PHA-stimulated PBMCs from healthy donors. Infected T lymphocytes were detected by intracellular...

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Share to CD4-Positive T-Lymphocytes
Share to HLA-A Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Identifiers

PMID: 17122895
DOI: 10.1007/s00705-006-0873-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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