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Article

Both memory and CD45RA+/CD62L+ naive CD4(+) T cells are infected in human immunodeficiency virus type 1-infected individuals.

Journal of virology - 1 Aug 1999

Ostrowski M A, Chun T W, Justement S J, Motola I, Spinelli M A, Adelsberger J, Ehler L A, Mizell S B, Hallahan C W, Fauci A S

Abstract excerpt

Cellular activation is critical for the propagation of human immunodeficiency virus type 1 (HIV-1) infection. It has been suggested that truly naive CD4(+) T cells are resistant to productive HIV-1 infection because of their constitutive resting state. Memory and naive CD4(+) T-cell subsets from 11 HIV-1-infected individuals were isolated ex vivo by a combination of magnetic bead depletion and...

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Identifiers

PMID: 10400736
DOI: 10.1128/JVI.73.8.6430-6435.1999
PMCID: PMC112723

Genes

CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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